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Bacteria and yeasts have been making food tastier for centuries: the curds so common in most Indian cuisines, the cheeses of Western cuisine, our fermented idli-dosa-dhokla batters, relishes of fermented fish, and an assortment of

alcoholic beverages. And yet it’s taken us a while to ascertain that they have more than taste benefits; they can have health benefits too.

About a century ago, Nobel laureate Ilya Ilyich Mechnikov, who was recognized for his work on phagocytosis, said, “Lactic acid bacteria can render a great service in the fight against intestinal putrefaction… (and can) postpone and ameliorate old age”.

In the 21st century, enter the cult of functional foods. Joining the race with older panaceas such as “low-fat”, “wholegrain” and antioxidant-rich “superfood” are “probiotics”, with their promise of a healthier life—probiotic is Greek for “for life” (to read more about probiotics, visit www.livemint.com/probiotic.htm).

In the ongoing debate about the actual benefits of probiotics, and all the hoopla over introducing specific strains of goodness into the gut (not every Bifidobacteria, Lactobacilli or other bacteria are worthy of a probiotic title, only those proven to have a positive effect), we sometimes overlook the fact that these bacteria already have a home...inside us.

Also Read Previous Food Factors columns

Bacteria in your belly, already

Probiotic foods may replenish or bolster stocks of beneficial bacteria in those who find their original levels of bacteria in the gut depleted by illness or antibiotics.

But probiotics aren’t introducing anything your body didn’t have in the first place. What must come entirely from outside, in fact, is not the bacteria but the stuff they feed on: prebiotics.

After all, the reason these symbionts live in our digestive tracts is to partake of the food we eat. The foods these bacteria prefer are indigestible by humans: They are “nondigestible food ingredients that beneficially affect the host by selectively stimulating the growth of one or a limited number of bacterial species in the colon, such as Bifidobacteria and Lactobacilli which have the potential to improve host health” (Ashwell M., Concepts of Functional Foods, 2002). That is, in fact, the textbook definition of “prebiotics” (meaning “before life”).

Prebiotics, nourishment by proxy

A true prebiotic must abide by three rules.

Rule 1: It must not be broken down in the stomach, nor be absorbed in the gastrointestinal tract. That is, it must get to the bacteria, not get eaten by the human host.

Rule 2: It must then be fermented by these bacteria.

Rule 3: It must preferentially nourish those bacterial strains that are known to benefit the host’s health.

So prebiotics seem designed to nourish the bacteria that nourish your health. Indeed, some prebiotics go one step further. Studies from the last decade suggest that some prebiotics help us absorb minerals such as calcium and magnesium better; others may protect us against colorectal diseases, or even ameliorate our lipid levels (cholesterol and triglycerides).

Building blocks of bacterial benefit

These are foods so old that some of us are in danger of disregarding them. Prebiotics are found in common foods: whole grains such as (unprocessed) oats, wheat and barley, legumes, fruits such as bananas, vegetables such as onions, garlic, tomatoes and leafy greens, and even the humble jicama (sankalu). Researchers know them as inulins, oligosaccharides, galactans, polydextrose and polyols. For many scientists, all this recent research is directed towards the Holy Grail of immunity-in-a-pill, a mix of probiotics and prebiotics, called “synbiotics”. But for layfolk, it may be a rediscovery of old-fashioned wholesomeness.

The author is a deputy features editor at Mint.

Write to us at businessoflife@livemint.com

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witan Said:


Sorry, this article is full of misinformation. It is not possible for me to correct all of them, but I give below one or two glaring instances. ¶"the reason these symbionts live in our digestive tracts is to partake of the food we eat." -- The bacteria that "partake" of the food are called "commensals", not symbionts. ¶"The foods these bacteria prefer are indigestible by humans" -- Totally wrong! The concept is probably applicable to ruminants like the cow, not to humans. The bacteria in the digestive system of cattle break down cellulose, for example, and make it available to the host. The situation in humans is quite different. For example, milk sugar, lactose, is not digestible by most adult humans, and usually it is broken down by bacteria in the large intestine. The products are not available for human nutrition, but this bacterial activity in the large intestines only causes flatulence, diarrhoea and often intense discomfort to the humans. There are also other foods, like soya bean, that have "indigestible" constituents that create similar problems.

Posted On 8/25/2009 11:42:46 AM
Re: Manidipa Said:


Thanks for your comment, Witan. Interesting pseudonym, by the way.However, to address your concerns: (1) Commensalism is a kind of symbiosis. Symbiosis is parasitic when the host is harmed, but if a host is benefitted or unharmed, the symbiont and the host are said to be in a commensal relationship. Here's one of many links that could clarify this: http://web.uconn.edu/mcbstaff/graf/GenSym/GenSym.htm You are quite right that humans do not need bacteria to break down their carbohydrates and make them digestible as in ruminants, such as cattle. However, the point of probiotic bacteria is not that they make the indigestible food into a digestible nutrient for us. Rather, they take the indigestible compounds in some foods for their own use. Yes, you're right, some bacteria ferment certain foods, and that can indeed cause flatulence. However, the premise of a probiotic strain of bacteria is that they will cause BENEFIT by their action, and these are the bacteria that act upon the indigestible part of some foods, called prebiotics. If you are keen on a detailed study, please see this one, a fairly early and comprehensive paper: http://www.ajcn.org/cgi/content/full/69/5/1052S I would draw your attention particularly to the first line under the heading 'Prebiotics', which begins "A prebiotic is a indigestible food ingredient that beneficially affects the host..."

Posted On 8/25/2009 3:08:41 PM
kavita Said:


An excellent article. Now that our palate, body and mind have become accustomed to probiotics and their benefits (some like my son even love it), it’s high time we got acquainted to PREBIOTICS - food for probiotics. The logic for their inclusion in our menu is simple - the more we can feed and care for our ‘good bugs’, the healthier we will be. Unfortunately these are not yet available and marketed in easy small bottles (one gulp and you are done!) but nevertheless as Manidipa's exhaustive list of food sources lists - they are very easily had. I'd like to add two more sources here - rye and leeks.

Posted On 8/26/2009 12:12:12 PM
witan Said:


Re: Manidipa's reply posted on 8/25/2009 3:08:41 PM. ¶ The first link you have provided http://web.uconn.edu/mcbstaff/graf/GenSym/GenSym.htm is not of specific relevance to a discussion on probiotics and prebiotics in HUMAN NUTRITION. As for the second link, http://www.ajcn.org/cgi/content/full/69/5/1052S, which is to what you call a “comprehensive paper”, the opening sentence in the Abstract itself says most of it: “The microbiota of the *human large intestine* influences health and well-being”. No bulk nutrient and almost no trace nutrient (e.g. vitamins) required by humans is absorbed from the *large intestine*, which is an excretory organ. In a healthy human gastrointestinal tract, the bacterial population is almost entirely limited to the large intestine, and negligible in other parts. As a matter of fact, lactic acid bacteria that are promoted as “probiotics” for oral consumption, cannot survive the high acidity in the stomach and are killed off. If the bacteria are administered in “enteric coated” pills or capsules, they could reach the small intestines, but even then they cannot colonize the small intestines. They cannot colonize the large intestine either, because it is already full of other microorganisms, especially Escherichia coli (in humans). That is not to say that _dahi_ or yogurt, for example, has no beneficial effect. The enzyme lactase secreted by lactic acid bacteria is present in yogurt, and will survive for a short time in the stomach -- so when a teaspoon of yogurt is taken along with milk, it will help break down the milk sugar lactose, and prevent the undesirable consequences of ingesting lactose. Most adult humans do not have lactase in their digestive tracts, and cannot digest the milk sugar. However, ingesting a pure culture of the lactic bacteria will not give the same benefit, because there is no lactase present in such cultures.

Posted On 8/28/2009 4:54:09 PM
Re: Manidipa Said:


@Witan --- Not sure what your point is. The first link was certainly not intended to provide information on probiotics or prebiotics, but to clarify definitions of commensality. As for the second, I'm not sure I understand your problem with it. For the other points you raise, I don't think either I or the authors of the paper in that link have suggested any of the following: (a) nutrients are being absorbed from the large intestine as a result of ingesting either probiotics or prebiotics (b) any and all bacteria survive the acidic stomach and get to the intestines (I will repeat: only those that DO so and are found to benefit human health by researchers are considered as being "probiotic" (c) that the bacteria are colonizing the intestines by ousting others (you seem to be drawing a parallel with human colonial invasions, but this is simply not the case) (d) that the specific strains of lactic acid bacteria that are called probiotic are relevant for aid in digesting lactose. I will also take the liberty of noting that far from being bacteria-free, both ends of the gastrointestinal tract (mouth and anus) in fact are teeming with bacteria. As for the colon, Escherichia is most emphatically NOT the most common genus in the colon, Lactobacillus is (please see: http://aem.asm.org/cgi/content/abstract/68/7/3401). As for there being no bacteria in the stomach and small intestine, have you ever heard of Heliobacter pylorii? It is the stomach bacteria that causes ulcers, and is a resident even in healthy human stomachs. For more on this, please read here: http://www.enotes.com/microbiology-encyclopedia/microbial-flora-stomach-gastrointestinal-tract. If your point is simply to argue the usefulness or efficacy of probiotic foods, it's a subject I'm very interested in and would love to see some research or references to add to what I've already read! Links, please, witan, or even names of books you're reading? Or maybe even details of original research you have undertaken?

Posted On 9/2/2009 4:37:30 PM