My wife is undergoing the treatment with Sutent since February 2008. She was diagnosed with RCC in August 2005, operated on to remove the kidney & followed it up with radiation & chemotherapy. Now the metasis is in the sacrum portion of the spine. She has had a fair amount of side effects namely 1) Blood Pressure shooting up to 190/130 2) Rash on the upper thighs. 3) Fatigue 4) Swelling of Toes, eyelids, Nose tip amongst others. 5) Taste loss, and ulcers occuring in the mouth. 6) Acidity 7) Peeling of skin of the big toe The BP was pretty severe & the Doctor had to reduce the dosage + put the patient on complete bed rest for a couple of days + give tablets to bring down the BP. We are continuing with the treatment inspite of the side effects, hoping that the tumour will stop growing or reduce the rate of growth.