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Home / News / India /  As black fungus cases rise in India, AIIMS chief lists key factors to prevent mucormycosis

With the rising number of mucormycosis cases seen among Covid-19 patients in the country, All India Institute of Medical Science (AIIMS) director Randeep Guleria has listed three important factors to prevent the "black fungus" outbreak.

"We have to see at prevention of this outbreak," Guleria said, adding the three factors that are very important. "Good control of blood sugar levels, those on steroids must monitor blood sugar levels regularly, and be careful about when to give steroids and their dosage," the AIIMS Director said.

"Earlier, mucormycosis was commonly spotted in people suffering from diabetes mellitus, a condition where one's blood sugar (glucose) levels are abnormally high. Cancer patients undergoing chemotherapy, those who have had a transplant, and people taking immunosuppressants (medications that weaken the immune system) also used to get it. But now due to Covid-19 and its treatment, an increase in the number of cases is being witnessed," Guleria said.

"There are more than 20 cases of the fungal infection in AIIMS itself, all of whom are Covid positive. Many states have reported 400 to 500 cases, all among COVID patients," he added.

Why and how it affects Covid-19 patients during or post-recovery?

Medicines used in treating Covid-19 tend to bring down the count of lymphocytes. Lymphocytes are one of the three types of white blood cells whose job is to defend our body against disease-causing pathogens such as bacteria, viruses, and parasites. The reduced count of lymphocytes leads to a medical condition called lymphopenia, making way for opportunistic fungal infection in Covid-19 patients.

There is a higher chance of occurrence of mucormycosis in patients whose immune system is not functioning well, and since Covid-19 treatment tends to suppress the working of the immune system, it places such patients at a higher risk of contracting the black fungus infection.

Disease and Symptoms

Mucormycosis can be categorized depending on which organ of the human body it attacks. Signs and symptoms of the infection also vary depending on the affected body part.

  • Rhino orbital cerebral Mucormycosis: Infection occurs when fungal spores are inhaled. It infects the nose, orbit of eye / eye socket, oral cavity and can even spread to the brain. Symptoms include headache, nasal congestion, nasal discharge (green colour), pain in sinus, bleeding nose, swelling on face, lack of sensation on face and skin discoloration.
  • Pulmonary Mucormycosis: When spores are breathed in and reach the respiratory system, it affects the lungs. Symptoms are fever, chest pain, cough and coughing of blood.

The fungus can also infect the gastrointestinal tract, skin, and other organs but the most common form is Rhino cerebral Mucormycosis.

Preventive measures to be taken by Covid-19 patients:

People with the following medical conditions should be more careful, they should constantly monitor their health and also take the following preventive measures.

Diabetic Patient (uncontrolled diabetes) + Steroid usage + COVID Positive – all three combined together place one under high risk of getting this infection. Hence diabetic patients should always monitor and control their blood sugar level.

Misuse of steroids is also a cause of concern that directly affects one’s immune system.

Covid positive patients with a mild form of the infection should strictly avoid taking steroids. On the one hand, steroids are of no use in the treatment of mild Covid cases. On the other hand, taking steroids increases the risk of secondary infections like Mucormycosis. It leads to a high risk of fungal infection even after recovery from Covid-19. Hence if a Covid-infected person’s oxygen saturation level is normal, and he/she is categorized as clinically mild, steroids should be completely avoided.

Those who are taking steroids should also keep checking their blood sugar levels. In most cases, one who is not diabetic finds that after taking steroids, the blood sugar level shoots up to 300 to 400. Hence, it is essential to continuously monitor one’s sugar level.

“High dosage of steroids being taken by Covid-19 patients is of no use. Mild to moderate doses are good enough. As per the data, steroids should be given only for 5 to 10 days (maximum). Moreover, steroids increase the blood sugar level which can then become hard to control." This can in turn increase the chance of fungal infection, said Prof. Guleria.

Wearing masks is compulsory. Fungal spores found in air can easily enter the body through the nose. This makes masking up doubly important, in preventing infection. People who work at or visit construction sites should specifically pay attention to this.

Where are these fungi found?

Mucormycosis is caused by a group of molds called mucormycetes. It is naturally found in air, water and even food. It enters the body through fungal spores from the air or can also occur on skin after a cut, burn, or skin injury.

Other Preventive measures to be followed:

  • Cleaning and replacement of humidifiers (for those using Oxygen Concentrators)
  • Sterile normal saline should be used in the humidifier bottle and changed daily
  • Masks should be disinfected daily

Don’t miss even minor symptoms:

Pain and redness around eyes and nose, fever (usually mild), epistaxis (bleeding from the nose), nasal or sinus congestion, headache, cough, shortness of breath, vomiting of blood, altered mental status and partial loss of vision.

Responsibilities of doctors, other healthcare workers

While discharging Covid-19 patients, advise about early symptoms or signs of Mucormycosis; such as facial pain, blockage, excessive discharge, loosening of teeth, chest pain and respiratory insufficiency.

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