Home/ News / India/  India's first mRNA Covid-19 vaccine likely to be available soon

India's first mRNA Covid-19 vaccine is likely to be available soon as the Subject Expert Committee (SEC) in a meeting held on Friday recommended Emergency Use Authorisation (EUA) for the same, news agency ANI reported quoting sources.

The Drugs controller general of India (DCGI) is expected to give Emergency Use Authorisation to Gennova's mRNA vaccine  any time soon.

The SEC under India's drug regulator found data submitted by Gennova Biopharmaceuticals satisfactory in the Friday meeting, people in the know told ANI.

The company submitted data in April and provided additional data in May.

"Product development using innovative technologies like mRNA, a fourth-generation vaccine platform stable at 2 to 8 degrees Celcius, is a challenging journey during pandemic times,"said Gennova's spokesperson, ANI reported.

The company has conducted phase 2 and phase 3 data trials on 4000 participants to evaluate vaccine safety, immunogenicity and tolerability.

The vaccine - GEMCOVAC-19 - is the country's first homegrown mRNA COVID- 19 vaccine and is seen as a game-changer for the healthcare industry.

What are mRNA vaccines?

Messenger RNA is a type of RNA that is necessary for protein production. In cells, mRNA uses the information in genes to create a blueprint for making proteins. Once cells finish making a protein, they quickly break down the mRNA. mRNA from vaccines does not enter the nucleus and does not alter DNA.

How mRNA COVID-19 vaccines work?

  • First, mRNA COVID-19 vaccines are given in the upper arm muscle. After vaccination, the mRNA will enter the muscle cells. Once inside, they use the cells’ machinery to produce a harmless piece of what is called the spike protein. 
  • The spike protein is found on the surface of the virus that causes COVID-19. After the protein piece is made, our cells break down the mRNA and remove it.
  • Next, our cells display the spike protein piece on their surface. Our immune system recognizes that the protein does not belong there. This triggers our immune system to produce antibodies and activate other immune cells to fight off what it thinks is an infection. 
  •  Any side effects from getting the vaccine are normal signs the body is building protection.

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Updated: 28 Jun 2022, 01:13 PM IST
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