PremiumThe Indian Council of Medical Research or ICMR has proposed to conduct a clinical trial for 'randomised evaluation of Covid-19 therapy' along with the University of Oxford and an expression of intent for participation in it has been sought from hospitals.
The trial -- 'India-UK RECOVERY (Randomised Evaluation of COVID-19 therapy)' -- will be a multi-centre, adaptive platform trial on Covid patients, ICMR on Friday said.
"ICMR, Delhi, along with the University of Oxford is proposing to conduct a multi-centre, adaptive platform trial on COVID-19 patients, titled 'India-UK RECOVERY (Randomised Evaluation of COVID-19 therapy)," it said.
"An expression of intent is sought from institutions/hospitals with the facilities and capacity available to participate in the clinical trial which will enroll participants admitted in their hospitals," it added.
The intervention arm of the trial will include baricitinib and the control arm will receive local standard of care. The trial will be initiated only after obtaining requisite regulatory and ethics approvals, as per the ICMR.
"Institutions which are interested to collaborate with ICMR on undertaking this trial may express their interest by providing the details," it said.
Informed consent has to be obtained from each patient before enrolment into the study.
The protocol of the study describes a randomised trial among patients hospitalised for coronavirus. All eligible patients are randomly allocated between several treatment arms, each to be given in addition to the usual standard of care in the participating hospital.
At the Indian sites, all participants aged 18 years or above will be allocated to baricitinib vs. no additional treatment. The interim trial results will be monitored by an independent Data Monitoring Committee.
Meanwhile, India logged 43,393 new coronavirus infections taking the total tally of COVID-19 cases to 3,07,52,950, while the active cases have declined to 4,58,727, according to the Union Health Ministry data updated on Friday.
The death toll has climbed to 4,05,939 with 911 fresh fatalities.
The active cases comprise 1.49 per cent of the total infections and the national COVID-19 recovery rate stands at 97.19 per cent, the data updated at 8 am showed.
A decrease of 1,977 cases has been recorded in the active COVID-19 caseload in a span of 24 hours.
As many as 17,90,708 tests were conducted on Thursday taking the total cumulative tests conducted so far for detection of COVID-19 in the country to 42,70,16,605, while the daily positivity rate was recorded at 2.42 per cent.
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