Three people have died following a hantavirus outbreak on a luxury cruise ship, while five additional cases that are confirmed or suspected have also been reported, according to a Reuters report.
Meanwhile, AP reported, citing Dutch officials, that about 40 passengers from a cruise ship hit by a deadly hantavirus outbreak have disembarked on St. Helena.
However, the World Health Organization (WHO) has stated that the overall risk to public health is still considered low.
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Hantaviruses are rodent-borne viruses that can infect humans. They typically spread through contact with infected rodents, their urine, droppings, or saliva, often becoming airborne when cleaning infested areas. The Andes strain, found on the cruise ship, is also known to spread through close human-to-human contact.
Symptoms of Hantavirus infection usually appear one to eight weeks after exposure and can include fever, muscle aches, and gastrointestinal issues. In severe cases, particularly with the Andes strain, it can lead to Hantavirus cardiopulmonary syndrome, characterized by fluid in the lungs and heart complications.
There is no specific treatment for Hantavirus; care is supportive, focusing on rest, fluids, and potentially breathing support. While outbreaks like the one on the cruise ship are unusual, the World Health Organization considers the overall risk to the general public to be low.
The outbreak is significant because it involves the Andes hantavirus strain, which is one of the few known strains capable of limited human-to-human transmission. The close quarters of a cruise ship can make such rare transmission patterns more visible.
Authorities suspect the Hantavirus outbreak on the cruise ship MV Hondius may have originated from exposure to rodents in Ushuaia, Argentina, before passengers boarded. The Andes virus strain is commonly found in South America, particularly Argentina and Chile.
The WHO said on Wednesday that there have been eight known and suspected cases of hantavirus connected to the cruise ship MV Hondius, including three deaths.
According to the ship’s operator, Oceanwide Expeditions, three passengers were evacuated on Wednesday, two of them in serious condition. One patient is currently in intensive care in South Africa, while another former passenger who returned to Switzerland is receiving treatment in Zurich, Reuters reported.
Barely 150 people are remaining on board the ship, which has been stranded off Cape Verde since Sunday and was expected to continue its journey to Spain’s Canary Islands later on Wednesday.
Passengers who are not showing any symptoms, currently all those still on the vessel—will be allowed to disembark once it reaches the Canary Islands. Spain has said that its 14 nationals will be placed in quarantine at a military hospital, while all other passengers will be repatriated and quarantined according to their respective countries’ health protocols, Reuters reported.
Hantaviruses are viruses carried by rodents that can infect humans and cause disease. According to the WHO, there are an estimated 10,000 to 100,000 human cases worldwide each year, with the severity depending on the specific strain.
The strain detected on the ship has been identified as Andes hantavirus, which is usually found in Argentina and Chile. The Hondius had departed from Argentina on April 1.
Hantavirus spreads primarily through rodents, infecting people via contact with rats or mice, or their urine, droppings, or saliva — often when the virus becomes airborne during cleaning of infested areas. Less commonly, it spreads through contaminated surfaces.
The Andes virus is the only known hantavirus that can spread through close, prolonged human-to-human contact.
The WHO said on Wednesday it had not been informed of any changes in the virus that could have made it more transmissible in this way, but it believes there has been some human-to-human spread on board the Hondius, Reuters reported.
Studies have shown that the virus tends to transmit in the early stages of a patient's sickness, when they have symptoms.
Maria Van Kerkhove, WHO Director of Epidemic and Pandemic Management, told Reuters in an interview on Wednesday that close contact meant something like sharing a cabin or bunk room on board the ship. She said experts were working to establish which passengers were high-risk or low-risk, based on their contacts with passengers who were unwell.
Hantaviruses, common in different parts of the world, cause different symptoms or diseases — and some cause none at all.
“Symptoms typically begin one to eight weeks after exposure and may include fever, muscle aches and gastrointestinal issues, according to the WHO, although a typical incubation period would be closer to around two to three weeks,” said Andrew Pollard, a professor at Oxford University's Pandemic Sciences Institute, as reported by Reuters.
The Andes hantavirus and other hantaviruses in the Americas can cause hantavirus cardiopulmonary syndrome, which progresses quickly and leads to fluid buildup in the lungs along with heart complications. Fatality rates from hantavirus cardiopulmonary syndrome are up to 50%, the WHO says, compared to 1-15% from the infections common in Asia and Europe.
There is no specific treatment for infection from hantavirus, so current therapy focuses on supportive care, including rest and fluids. Patients may need breathing support such as a ventilator.
Prevention focuses on limiting contact with rodents through measures like keeping areas and surfaces clean.
During outbreaks, contact tracing can give others potentially exposed to the virus earlier access to hospital care, improving outcomes and preventing further spread.
The cruise ship outbreak is unusual, although disease outbreaks of illnesses such as influenza are more common on ships due to proximity of people on board, experts said, according to the report.
The current outbreak is being investigated by experts from the WHO and various countries but the risk to the public remains low, the U.N. health agency says, as reported by Reuters.
Pollard said that identifying the virus responsible for the outbreak made it possible to manage the situation through public health measures on the ship, including containment and isolation, as well as through monitoring protocols in countries receiving returning passengers.
More broadly, hantaviruses continue to circulate globally, with the WHO warning about a rise in cases across the Americas in late 2025.
(With inputs from Reuters)
