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FILE - In this Thursday, April 23, 2020 file screen grab taken from video issued by Britain's Oxford University, showing a person being injected as part of the first human trials in the UK to test a potential coronavirus vaccine, untaken by Oxford University in England. A key researcher at the University of Oxford says scientists expect to report results from the late-stage trials of their COVID-19 vaccine by Christmas. Dr. Andrew Pollard, an expert in pediatric infection and immunity at Oxford, said ThursdayNov. 19, 2020 that research was slowed by low infection rates over the summer but the Phase III trials are now accumulating the data needed to report results.  (Oxford University Pool via AP, File) (AP)
FILE - In this Thursday, April 23, 2020 file screen grab taken from video issued by Britain's Oxford University, showing a person being injected as part of the first human trials in the UK to test a potential coronavirus vaccine, untaken by Oxford University in England. A key researcher at the University of Oxford says scientists expect to report results from the late-stage trials of their COVID-19 vaccine by Christmas. Dr. Andrew Pollard, an expert in pediatric infection and immunity at Oxford, said ThursdayNov. 19, 2020 that research was slowed by low infection rates over the summer but the Phase III trials are now accumulating the data needed to report results. (Oxford University Pool via AP, File) (AP)

Oxford-AstraZeneca Covid-19 vaccine can be 90% effective, results show

  • Positive high-level results from an interim analysis of clinical trials of AZD1222 in the UK and Brazil showed the covid vaccine was highly effective in preventing COVID-19

British-Swedish drugmaker AstraZeneca said on Monday its covid vaccine for the novel coronavirus, developed along with the University of Oxford, could be around 90% effective under one dosing regimen. The British-Swedish drugmaker's preliminary trial results mark a fresh breakthrough in the fight against a pandemic that has killed nearly 1.4 million people and roiled the global economy. Earlier this week, Pfizer and Moderna had reported promising results from vaccine trials.

“Today marks an important milestone in our fight against the pandemic. This vaccine’s efficacy and safety confirm that it will be highly effective against COVID-19 and will have an immediate impact on this public health emergency," AstraZeneca chief executive Pascal Soriot said in a statement.

"Furthermore, the vaccine’s simple supply chain and our no-profit pledge and commitment to broad, equitable and timely access means it will be affordable and globally available, supplying hundreds of millions of doses on approval," he added.

"Positive high-level results from an interim analysis of clinical trials of AZD1222 in the UK and Brazil showed the vaccine was highly effective in preventing COVID-19, the primary endpoint, and no hospitalisations or severe cases of the disease were reported in participants receiving the vaccine," AstraZeneca said.

"One dosing regimen (n=2,741) showed vaccine efficacy of 90% when AZD1222 was given as a half dose, followed by a full dose at least one month apart, and another dosing regimen (n=8,895) showed 62% efficacy when given as two full doses at least one month apart. The combined analysis from both dosing regimens (n=11,636) resulted in an average efficacy of 70%. All results were statistically significant (p<=0.0001). More data will continue to accumulate and additional analysis will be conducted, refining the efficacy reading and establishing the duration of protection," it added.

Professor Andrew Pollard, Chief Investigator of the Oxford Vaccine Trial at Oxford, said: “These findings show that we have an effective vaccine that will save many lives. Excitingly, we’ve found that one of our dosing regimens may be around 90% effective and if this dosing regime is used, more people could be vaccinated with planned vaccine supply. Today’s announcement is only possible thanks to the many volunteers in our trial, and the hard working and talented team of researchers based around the world."

AstraZeneca said it is "making rapid progress in manufacturing with a capacity of up to 3 billion doses of the vaccine in 2021 on a rolling basis, pending regulatory approval. The vaccine can be stored, transported and handled at normal refrigerated conditions (2-8 degrees Celsius/ 36-46 degrees Fahrenheit) for at least six months and administered within existing healthcare settings."

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