The study also demonstrates that the immunity built up from previous non-SARS-CoV-2 coronavirus infections does not prevent individuals from getting COVID-19
Being previously infected with coronaviruses that cause the 'common cold' may decrease the severity of COVID-19, according to researchers, including one of Indian origin, who said the finding could have significant implications on vaccine development.
The study, published in the Journal of Clinical Investigation, also demonstrates that the immunity built up from previous non-SARS-CoV-2 coronavirus infections does not prevent individuals from getting COVID-19.
After adjusting for age, gender, body mass index, and diabetes mellitus diagnosis, COVID-19 hospitalised patients who had a previous positive CRP-PCR test result for a coronoavirus had significantly lower odds of being admitted to the intensive care unit (ICU).
They also had lower trending odds of requiring mechanical ventilation during COVID, the researchers said.
The probability of survival was also significantly higher in COVID-19 hospitalised patients with a previous positive test result for a common cold coronoavirus.
However, a previous positive test result for a coronavirus did not prevent someone from getting infected with SARS-CoV-2.
"Our results show that people with evidence of a previous infection from a "common cold" coronavirus have less severe COVID-19 symptoms," said Manish Sagar, an associate professor at Boston University School of Medicine and the study's co-corresponding author.
The researchers also found that immunity may prevent COVID-19 in ways that are different from preventing infection by SARS-CoV-2.
This is demonstrated by the fact that the patient groups had similar likelihoods of infection but differing likelihoods of ending up in the ICU or dying, they said.
This story has been published from a wire agency feed without modifications to the text. Only the headline has been changed.
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