Jauan Jennings injury update: Will 49ers WR play NFL Week 3 game against Cardinals? Check details

Jauan Jennings, San Francisco 49ers wide receiver, has been a standout performer early in the 2025 NFL season, despite battling health concerns. However, he has been listed as questionable for the upcoming Week 3 game against the Arizona Cardinals due to shoulder and ankle injuries. According to a report by ESPN, Jennings will not play and will be out.

This news comes alongside another blow for the 49ers, as quarterback Brock Purdy will also miss the matchup due to a toe injury, with Mac Jones stepping in as the starter and Adrian Martinez as the backup.

Impact of Jennings’ absence

Jauan Jennings’ absence will be felt in the 49ers’ receiving corps. As a reliable target known for his physicality and ability to make contested catches, he provided a unique dynamic to the offense. With Jennings sidelined, the team will likely lean more heavily on other receivers like Deebo Samuel and Brandon Aiyuk to fill the void. Tight end George Kittle could also see an increased role in the passing game, provided he’s healthy and active.

The 49ers’ decision to rest Jennings may be a precautionary measure to ensure his long-term health, especially with a demanding season ahead. Shoulder and ankle injuries can be tricky, and limited practice time suggests the team is prioritizing his recovery over rushing him back for a single game.

Quarterback challenges

The San Francisco 49ers are also navigating challenges at the quarterback position. Brock Purdy’s toe injury has ruled him out for Week 3, thrusting Mac Jones into the starting role. Jones, who has experience as a starter from his time with the New England Patriots, will need to quickly adapt to leading the 49ers’ offense. Adrian Martinez, a less experienced option, will serve as the backup, adding uncertainty to the team’s quarterback depth.

San Francisco 49ers NFL schedule

49ers at Seattle – Mon, Sep 8

49ers at New Orleans – Sun, Sep 14

49ers vs Arizona – Mon, Sep 22

49ers vs Jacksonville – Mon, Sep 29

49ers at Los Angeles – Fri, Oct 3

49ers at Tampa Bay – Sun, Oct 12

49ers vs Atlanta – Mon, Oct 20

49ers at Houston – Sun, Oct 26

49ers at New York – Sun, Nov 2

49ers vs Los Angeles – Mon, Nov 10

49ers at Arizona – Mon, Nov 17

49ers vs Carolina – Tue, Nov 25

49ers at Cleveland – Sun, Nov 30

BYE WEEK – Week 14

49ers vs Tennessee – Mon, Dec 15

49ers at Indianapolis – Tue, Dec 23

49ers vs Chicago – Mon, Dec 29

49ers vs Seattle – TBD